Ashxatanqner

The covariates tested in the base population PK model for their effects on CL₁ and CL_dos were sex, race, Zdiag, age, Latin Sites dating site weight and ActD. According to the results of the SCM methodology, none of the studied covariates provided a significant improvement in the overall fit.

3.dos Effectiveness number data model

Profile cuatro portrays the new VPC of one’s efficacy levels, and that found an excellent concordance anywhere between observed and model-predict changes having a small overprediction from the odds of stages 1. There was a slight underprediction of the probability of level 2. Dining table cuatro gets the fresh and you will private predicted change probabilities with each other which have a representation-built data of applied serving levels (10, 29 and sixty U/kg) all the 2 weeks.

4 DISCUSION

A people PK model might have been properly created to characterize as well the latest enzyme activity when you look at the plasma and you will leukocytes during the GD1 patients treated that have ERT using observations by the calculating lysosomal and you may low-lysosomal glucocerebrosidase. Շարունակել դիտել …

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